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2-Hydroxyisocaproic acid

Synonyms: HICA

2-hydroxyisocaproic acid (HICA), an amino acid derivative, has broad antibacterial activity.

2-Hydroxyisocaproic acid Chemical Structure

2-Hydroxyisocaproic acid Chemical Structure

CAS No. 498-36-2

Purity & Quality Control

Batch: E065201 DMSO]26 mg/mL]false]Water]26 mg/mL]false]Ethanol]26 mg/mL]false Purity: 99%
99

2-Hydroxyisocaproic acid Related Products

Biological Activity

Description 2-hydroxyisocaproic acid (HICA), an amino acid derivative, has broad antibacterial activity.
In vitro
In vitro

2-Hydroxyisocaproic acid is not cytotoxic and genotoxic at concentrations <10 mg/mL. At the concentration of 1 mg/mL, 2-Hydroxyisocaproic acid is significantly less cytotoxic than calcium hydroxide.[2]
Cell Research Cell lines Human periodontal ligament fibroblasts
Concentrations 1-40 mg/mL
Incubation Time 24, 48 h
Method

Human periodontal ligament fibroblasts are exposed to varying concentrations of HICA (1, 2.5, 5, 10, 20, and 40 mg/mL) for 24 hours, and a dose-response curve is generated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay. Immunofluorescence for 2 markers of DNA double-strand breaks, phosphorylated γH2AX and 53BP1, is used to establish the genotoxicity of HICA at various half maximal effective concentration (EC50) fractions. Cytotoxicity and genotoxicity of HICA and calcium hydroxide at 1 mg/mL are compared at 24 and 48 hours using the same methods.
In Vivo
In vivo

2-Hydroxyisocaproic acid reduces expression of matrix metalloproteinase 9 (MMP-9) and myeloperoxidase (MPO) in a murine chamber model of C. albicans biofilm, compared to those of chambers containing caspofungin and PBS.[3]
Animal Research Animal Models Murine chamber model of C. albicans biofilm(male CD1 mice )
Dosages 5% (wt/vol)
Administration s.c.

Chemical Information & Solubility

Molecular Weight 132.16 Formula

C6H12O3
CAS No. 498-36-2 SDF --
Smiles CC(C)CC(O)C(O)=O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 26 mg/mL ( (196.73 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 26 mg/mL

Ethanol : 26 mg/mL


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In vivo
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